Outer-retinal expression
Human decorin expression demonstrated in the outer retina after intravitreal administration.
Therapeutic program / Wet AMD
Gene therapyTargeting fibrosis
and neovascularization.
AAV-IKV–Decorin combines retinal gene delivery with an endogenous regulator of extracellular matrix and growth-factor signaling.
Scientific evidence
Demonstrated biological activity.
Published mouse studies · intravitreal AAV-IKV–Decorin [1]
Anti-neovascular activity
Reduced choroidal neovascularization in the laser-induced model.
Antifibrotic activity
Reduced α-SMA-positive fibrotic responses in experimental ocular lesions.
Therapeutic approach
Beyond VEGF alone.
The program addresses the vascular and fibrotic components of wet AMD. Decorin’s combined biological activity supports a differentiated gene therapy approach, with a rationale for fibrosis-directed treatment alongside control of neovascularization.
- Therapeutic candidate
- AAV-IKV–Decorin
- Delivery route
- Intravitreal
- Biological focus
- Fibrosis + neovascularization
Supporting sources
[1] Mishra, Cashman & Kumar-Singh. 2025. Intravitreal decorin gene delivery. PMID: 39884544. ↗
Strategic partnerships
Start with the science.
Technology collaborations, strategic partnerships and investment discussions.